ANALYSIS OF VIBRIO CHOLERAE GENOME SEQUENCES REVEALS UNIQUE RTXA VARIANTS IN ENVIRONMENTAL STRAINS AND AN RTXA-NULL MUTATION IN RECENT ALTERED EL TOR ISOLATES

Analysis of Vibrio cholerae Genome Sequences Reveals Unique rtxA Variants in Environmental Strains and an rtxA-Null Mutation in Recent Altered El Tor Isolates

ABSTRACT Vibrio cholerae genome sequences were analyzed for variation in the rtxA gene that encodes the multifunctional autoprocessing RTX (MARTX) toxin.To accommodate genomic analysis, a discrepancy in the annotated rtxA start site was resolved experimentally.The correct start site is an ATG downstream from rtxC resulting in a gene of 13,638 bp an

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